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Good, and Laura I. Becker, Kristina M. Hettne, Erik M. Otemaier, M. Steffens, R. Raittz, A. Brawerman, J. Becker, Saber A. Akhondi, Zubair Afzal, Erik M. Furlong, Benjamin M. Good, and Andrew I.

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Kasthurirathne, Brian E. Lowe, Noel M. O'Boyle, and Roger A. An exploration through the lens of the Gene Ontology Jonathan M. Mortensen, Natalie Telis, Jacob J.

Published online Nov 5. Gonzalez, Tasnia Tahsin, Britton C.

Goodale, Anna C. Greene, and Casey S. Thompson, P. Systematic Reviews, , Mazandu, Emile R. Chimusa, Mamana Mbiyavanga, and Nicola J. This model defines the specifications of the tool in a descriptive form, which makes the developer difficult for defining the specifications without predefined knowledge about the domain.

Diasuite [ 83 ] is a tool that allows the designer to define the taxonomy of specific application environment by using the existing application model. It has its own simulation tool to simulate the working of the application with the prewritten specification of the application. These tools are taken as reference for the tool-based development.

Limitations of the Existing Work From the observation of the literature survey, context-aware middleware is working on three different aspects as shown in Figure 5. The first aspect of the context-aware middleware concerns on domain on which it is operating, such as smart home, smart office, smart class, and smart hospital. The second aspect of the context-aware middleware focuses on the various devices operating on the pervasive smart environment and devices involved are dynamic or fixed to what extend is the great challenge.

Figure 5: Different aspects of context-aware middleware. The third aspect of the context-aware middleware deals with the context of the diverse domain environment. Context predicts the situation of the pervasive smart environment and adapts according to it.

The different contexts are the location, time, device, operation, and so on, and the main objective is to assess how many contexts can the application support. From the study, it may be observed that there are mainly three reasons to state middleware is specific to the application: 1 Context-aware middleware architecture is specific to the pervasive applications.

There is no generic context-aware middleware architecture to support diverse domain applications. From the literature survey, existing context-aware middleware architecture exhibits the limited number of nonfunctional qualities, and also, they are implicitly stated. Most of the existing context-aware middleware are biased of specific aspects like service aspect alone or only to context aspect or particularly to the device aspect.

Conclusions The evolution of pervasive computing is presented. Various pervasive applications are obtained from the literature and classified according to their domain.

1 Introduction

The different architectures for pervasive computing are analyzed, and it is found that context-aware middleware architecture provides a better solution to build pervasive application. In order to better understand the demands of stakeholders of context-aware middleware, a set of different aspects of context-aware middleware are derived from the literature and presented. Context-aware middleware is classified based on three aspects such as context aspect, device aspect, and service aspect.

Classification of the context-aware middleware has been given to obtain a clear understanding about the requirements of the different aspects.

On analyzing the requirements of the context-aware middleware, the limitations are obtained, and the scope for the development of generic context-aware middleware is reported. Conflicts of Interest The authors declare that they have no conflicts of interest. References M. Kidd, R.

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BMC Genomics. Front Genet. Mar Epub May Brief Bioinform. Nature Communications. Stem Cells. Nature Systems Biology and Applications.

Mar 3, Kofler, and W. Metabolites , 2, For example, a typical approach, FingerID Heinonen et al. Breath Res. In the second part, we show that our measure can also be employed for finding statistically significant differences between Hi-C contact maps.

Ion Mobil. Diasuite [ 83 ] is a tool that allows the designer to define the taxonomy of specific application environment by using the existing application model. Our research focuses on supervised learning, where the common scheme is to learn a mapping from spectra to structures.

Romero Diaz, Nicole P.

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